Meddling fat causes diabetes in obese

Scientists claim to finally have found a link between obesity and diabetes inflammation —causing cells in fatty tissue cause insulin resistance. An international team, led by University of New South Wales, has found the link, which it claims may pave the way for new anti-inflammatory treatments which prevent insulin resistance and other complications associated with obesity. “We have shown that insulin resistance in human obesity is closely related to the presence of inflammatory cells in fat tissue, in particular a population of macrophage cells,” Prof. Len Harrison, who led the team, said. Macrophages, white blood cells derived from the bone marrow, are immune cells that normally respond to infections. In obese people, macrophages move into the fat tissue where they cause inflammation and release cytokines, which are chemical messenger molecules used by all the immune cells to communicate. Certain cytokines cause cells to become resistant to the effects of the hormone insulin, leading to diabetes. The scientists have based their findings on an analysis of the fat tissue of more than 100 people who had undergone lapband surgery.

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